Univariate logistic analysis of hub genes in anaphylactic dataset GSE69063 revealed that IL1R2 (p < 0.001, AUC = 0.797, 95% CI 0.679-0.916), DUSP1 (p = 0.002, AUC = 0.719, 95% CI 0.593-0.844), MMP9 (p = 0.003, AUC = 0.706, 95% CI 0.577-0.835), and CLEC4D (p < 0.001, AUC = 0.888, 95% CI 0.803-0.974) were significantly correlated with anaphylaxis as continuous variables (Figure 9A). Here, IL1R2 is linked to anaphylaxis.