HFpEF: heart failure with preserved ejection fraction; SGLT2i: sodium-glucose cotransporter 2 inhibitors; HF: heart failure; AF: atrial fibrillation; MRA: mineralocorticoid receptor antagonists; LVEF: left ventricular ejection fraction; ARB: angiotensin receptor blockers; ARNi: angiotensin receptor/neprilysin inhibitors. The gene discussed is SLC5A2; the disease is heart failure.