We identified 2.7 times more somatic SVs (focal deletions and duplications ≤5 Mb, insertions, inversions, inter and intrachromosomal translocations) in ETV6::RUNX1+ compared with HD BCP-ALL (n = 625 versus n = 219 SVs, respectively) (Figure 3A and 3B). The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.