The identification of genes such as ETV6, BTG1, STAG2, MANBA, TBL1XR1, and NSD2 that were affected by double hits of SVs and SNVs/indels demonstrates the power of combining OGM and WES for comprehensive determination of somatic alterations in BCP-ALL. This evidence concerns the gene TBL1XR1 and acute lymphoblastic leukemia.