The latter regions are increasingly recognized in the field as possibly having functional effects on leukemia genomes through enhancer deletions, hijacking, and topically associated domain disruption, leading to gene dysregulation.40–42 Of note, we identified 4 intergenic MARs located in proximity (20 kb) of genes including 1q32.2 (−6 kb; CD55), 21q22.11 (−20 kb; ATP5PO), and 22q12.1 (−0.2 kb; XBP1). This evidence concerns the gene ATP5PO and leukemia.