In addition, CREBBP mutations are more prevalent in recurrent HD BCP-ALL.24 Consistently, one of the HD BCP-ALL relapses in our study already had a CREBBP mutation (p.Gln1491Lys) at the time of diagnosis, which is located in the HAT domain and was previously described in relapse prone HD BCP-ALL.49 Here, CREBBP is linked to acute lymphoblastic leukemia.