The 2 most frequent genetic subtypes, encompassing 50%–55% of all childhood BCP-ALL cases are ETV6::RUNX1-translocated (t[12;21][p13;q22]) BCP-ALL and classical hyperdiploid (HD) BCP-ALL, harboring about 51–67 chromosomes per leukemic cell and comprise heterozygous di-, tri-, and tetrasomies.1 Both genetic entities usually have excellent therapy responses. This evidence concerns the gene RUNX1 and acute lymphoblastic leukemia.