IL10 and neoplasm: Anti-inflammatory factors such as IL-10 and PGE2 secreted by other immune-infiltrating cells and the tumor cells themselves suppress inflammatory activity.101 Type 2 CD4+ T helper cells can secrete IL4/IL13, which promotes a pro-resolution macrophage phenotype, suppressing a pro-inflammatory phenotype.102 Cancer-associated fibroblasts can deposit collagen, increasing extracellular matrix (ECM) density, which can promote a pro-resolution phenotype in macrophages.