Of note, in the tumor itself, circadian variations in frequency of CD86+ macrophages was observed, but the peak of CD86+ cells was reversed from in peripheral tissues.72 It was not clear if this circadian variation in CD86 was due to circadian oscillation of phenotype in the TAMs (from a pro-inflammatory to a pro-resolution phenotype) or due to rhythmic recruitment of macrophages that adopted different polarization states. The gene discussed is CD86; the disease is neoplasm.