MiR-143 (miR-143-3p) and miR-145 (miR-145-5p) encapsulated in KLF2-transduced or shear-stress-stimulated HUVEC-EVs induced an atheroprotective HASMC phenotype and reduced AS in the aorta of Apolipoprotein E Knock-Out (ApoE(−/−)) mice (61), supporting the bioinformatic prediction of Xiang et al. (51). Here, KLF2 is linked to aortic stenosis.