IEIs includes STAT1 gain-of-function, IL-2 receptor common gamma chain deficiency, adenosine deaminase deficiency, CD40 ligand deficiency, and STAT3 deficiency, CARD9 deficiency, IFN-γ receptor 1 deficiency, RelB deficiency, and NFKB2 deficiency (Liu et al., 2022; Wang et al., 2022). This evidence concerns the gene STAT1 and hyperinsulinemic hypoglycemia, familial, 4.