Cytochrome P450 monooxygenase (mainly CYP2J2) and its mediated product 12,13-EpOME were upregulated in tumor cells from CRC patients and mouse models of CRC, which activated epithelial-mesenchymal transition (EMT) in vitro and promoted CRC cell invasion and migration in vivo. Here, CYP2J2 is linked to colorectal carcinoma.