CALR and colorectal carcinoma: Current evidence suggests that L. paracasei induce CRC cells apoptosis and inhibit their proliferation by regulating the expression of specific Bcl-2 family proteins, producing reactive oxygen species (ROS), inducing the translocation of calreticulin (CRT) and changing the cell cycle (Chondrou et al., 2018; Nozari et al., 2019).