In the view of drug targets, NDUFS4 or NDUFS7 is reported as the targeted gene by casticin or nebivolol for its role in inhibiting cell migration and invasion in mouse melanoma B16F10 cells (Shih et al., 2017), or in blocking complex I activity related colon and breast tumor growth (Nuevo-Tapioles et al., 2020), respectively. The gene discussed is NDUFS4; the disease is melanoma.