By adopting general features of immune-based groupings and incorporating transcriptomic and proteomic features, Clark DJ et al. divided clear cell renal cell carcinoma (ccRCC) cohort into four subtypes: CD8+ infiamed, CD8− infiamed, VEGF immune desert and metabolic immune desert (Clark et al., 2019). The gene discussed is CD8A; the disease is nonpapillary renal cell carcinoma.