NDUFS1 and neoplasm: Besides, we investigated the correlation between protein and mRNA levels of NDUFS1 in KIRC via cProSite, and we found that the correlation coefficient in adjacent normal tissue was 0.58 while in tumor was only 0.23 (Supplementary Figure S5A), indicating that NDUFS1 mRNA in tumor may be further epigenetically modified at post-transcriptional level.