In recent years, few whole exome sequencing (WES) and target gene panel testing-based studies have reported a few rare variants in LDLR (Awan et al., 2022; Chan et al., 2018; Beheshti et al., 2020) and APOB (Banaganapalli et al., 2017; Awan et al., 2021a)genes, however, the role of PCSK9 gene variants in Saudi FH patients is not yet reported. This evidence concerns the gene LDLR and familial hyperaldosteronism.