LDLR and coronary artery disorder: The prevention of LDLR recycling and hepatic LDL-C clearance by hepatocytes, and chronic elevation of LDL-C in the plasma leads to plaque formation in arterial walls, accelerates atherosclerosis, and eventually leads to the development of premature CAD (McGowan et al., 2019; Seidah and Prat, 2021).