It was found that RCC cell-derived sEVs can significantly suppress the secretion of cytokines, such as interleukin-2 and interferon-gamma, by T cells, and in addition, the presence of Fas ligands within these sEVs can induce T cell apoptosis through binding with Fas, thereby promoting immune evasion by tumor cells (28). Here, FAS is linked to renal cell carcinoma.