Sex dimorphism in response toFGF21 was reported earlier in obese Ay mice: FGF21 administrationdecreases hyperinsulinemia and hepatic lipid accumulation,increases muscle expression of genes involvedin fatty acid oxidation and insulin signaling only in obeseAy males (Makarova et al., 2021b). The gene discussed is FGF21; the disease is Hyperinsulinemia.