By exploring these diverse architectures of Feo among bacteria, we found that H. pylori—an important human pathogen for its causal relationship with peptic ulcers and gastric cancer (Herrera and Parsonnet, 2009; Plummer et al., 2015; de Martel et al., 2020)—exhibits a unique arrangement of the feo genes. Here, TNFRSF11A is linked to gastric cancer.