Indeed, GHRL had a significant association with the majority of marker sets of CD8+ T cells, B cells, monocytes, M2 macrophages, DCs, Th2, Th17, Treg, and T-cell exhaustion in STAD (Table 2), including CD8A, CD8B, CD19, CD86, CD163, BDCA-1(CD1C), GATA3, STAT6, STAT3, FOXP3, CCR8, CTLA4, and LAG3 (p<0.01). This evidence concerns the gene CTLA4 and gastric adenocarcinoma.