A promising approach using a conditionally active biologic (CAB) AXL-targeted antibody drug conjugate BA3011 CAB-AXL-ADC, BioAtla, LLC, Table 2, NCT 03425279) alone and in combination with a PD-1 inhibitor Nivolumab in patients with advanced solid tumors is currently getting tested in Phase I, and in adult and adolescent patients with advanced, refractory sarcoma is investigated in Phase II. The gene discussed is AXL; the disease is sarcoma.