We carried out the LASSO cox regression analysis of 8 eligible ARGs of BC patients in the TCGA-BRCA dataset, and tapped 6 central genes for establishing prognostic signature, namely Anoikis-Correlation Index (ACI) (Figures 2A, B), including MAD2L1, PLK1, LAMB3, TP63, CEACAM5 and PYCARD. This evidence concerns the gene PYCARD and breast cancer.