Figures 3B, D, F show that CPNE7-OE cells rapidly grew large tumors compared with controls. The Western Blot in Figures 3G, H show the low expression of CPNE7-KD and high expression of CPNE7-OE, respectively. Thus, CPNE7 overexpression can promote CRC tumor proliferation in vivo. This evidence concerns the gene CPNE7 and neoplasm.