CAFs secrete soluble factors, which include cytokines, chemokines, and growth factors such as interleukin 6 (IL-6), C-type lectin domain family 3 member B (CLEC3B), C-X-C motif chemokine 12 (CXCL12), and epidermal growth factor (EGF) to transform the TME to support tumor growth (59–62). This evidence concerns the gene CXCL12 and neoplasm.