Finally, despite the clear advantages of FIT over gFOBT in terms of specificity for human haemoglobin and analytical performance characteristics, when FIT was used at the f-Hb threshold that gave the same positivity as gFOBT, the ICP was essentially the same.29 This means that the main advantage of FIT over gFOBT is its quantitative power, and it must be appreciated that increased sensitivity for CRC is dependent on lowering the f-Hb threshold and that this in turn impacts on colonoscopy requirement. The gene discussed is GSTM1; the disease is colorectal carcinoma.