In head and neck squamous cell carcinoma (HNSCC), the oxidative stress induced by HO∙ modifies the expression of BRAK and IL-8 genes in human HNSCC cells via the EGFR/MEK/ERK pathway, thereby promoting angiogenesis and facilitating tumor progression [120]. The gene discussed is CXCL14; the disease is head and neck squamous cell carcinoma.