Ma et al. discovered that H2O2 amplifies the retention of phosphorylated extracellular signal-regulated kinase 1⁄2 (pERK1/2) in the cytoplasm and the binding of kinase pGSK3β (Tyr-216) in the peripheral primitive neuroectodermal tumor cell line SK-N-MC, under the stimulation of the Fibroblast-FGF2 system. The gene discussed is FGF2; the disease is neoplasm.