122 Pez Pez F. F. Dayan Dayan F. F. Durivault Durivault J. J. Kaniewski Kaniewski B. B. Aimond Aimond G. G. Le Provost Le Provost G.S. G.S. Deux Deux B. B. Clézardin Clézardin P. P. Sommer Sommer P. P. Pouysségur Pouysségur J. J. Reynaud Reynaud C. C. The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth. The gene discussed is AKT1; the disease is neoplasm.