An integrated genome‐wide association study suggests EBI2 as a negative regulator of the IRF7‐driven inflammatory network, which was associated with susceptibility to type 1 diabetes.[40] In line with this, we have elucidated that EBI2 suppresses JAK‐STAT activation via GNAI3, resulting in the reduced ISGs production to limit the progression of SLE. This evidence concerns the gene IRF7 and systemic lupus erythematosus.