An integrated genome‐wide association study suggests EBI2 as a negative regulator of the IRF7‐driven inflammatory network, which was associated with susceptibility to type 1 diabetes.[40] In line with this, we have elucidated that EBI2 suppresses JAK‐STAT activation via GNAI3, resulting in the reduced ISGs production to limit the progression of SLE. The gene discussed is GNAI3; the disease is type 1 diabetes mellitus.