A previous study has shown that 7α, 25‐OHC stimulation could induce β‐arrestin‐mediated internalization of EBI2.[14b] We observed that the transcription of enzymes for 7α, 25‐OHC biosynthesis, including CH25H and CYP7B1, was enhanced in PBMCs and monocytes of SLE patients, which is consistent with the increased plasma concentrations of 7α, 25‐OHC in SLE patients. Here, CH25H is linked to systemic lupus erythematosus.