Intriguingly, serum concentrations of these up‐regulated genes in Ebi2‐cKO monocytes were previously reported to be increased in SLE patients,[30] and TGF‐β3 was reported to negatively regulate SLE.[31] Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis also revealed that cytokine and cytokine receptor interaction were the top two enriched signaling pathways (Figure 6B). The gene discussed is GPR183; the disease is systemic lupus erythematosus.