Because virus infection such as Epstein–Barr virus has been reported in SLE patients,[26] we next infected EBI2‐deficient macrophages with the DNA virus herpes simplex virus 1(HSV‐1), which again resulted in a dramatic up‐regulation of Ifnb and Cxcl10 (Figure S4D, Supporting Information). This evidence concerns the gene IFNB1 and systemic lupus erythematosus.