The plasma concentration of 7α, 25‐dihydroxycholesterol (7α, 25‐OHC) was markedly increased along with the enhanced expression of the enzyme 25‐hydroxycholesterol 7alpha‐hydroxylase (CYP7B1) in peripheral blood mononuclear cells (PBMCs) of SLE patients. This evidence concerns the gene CYP7B1 and systemic lupus erythematosus.