GPR183 and systemic lupus erythematosus: This study has identified the increased plasma 7α, 25‐dihydroxycholesterol in patients with systemic lupus erythematosus (SLE), which binds to Epstein–Barr virus‐induced gene 2 (EBI2) to inhibit the type I interferon (IFN‐I) response in macrophages.