As cytokines secreted by activated immune cells such as macrophages and T cells could play important roles in the development of SLE, we treated PEMs with various cytokines and supernatants from anti‐CD3/anti‐CD28‐activated CD8+ T cells (CD8+ T C.M) to screen which factors could reduce EBI2 expression. The gene discussed is CD28; the disease is systemic lupus erythematosus.