Since we observed the elevated phosphorylation of STAT3 and STAT1 in PBMCs of SLE patients (Figure 4H and Figure S5E, Supporting Information), we asked whether blocking the JAK‐STAT signaling could reverse the enhanced IFN‐I response in EBI2‐deficient macrophages. The gene discussed is STAT1; the disease is systemic lupus erythematosus.