EBI2 is a well‐known chemotactic receptor that mediates the migration of various immune cells, including B cells, T cells, dendritic cells, astrocytes, and group 3 innate lymphoid cells, to sites containing the ligand 7α, 25‐OHC.[16, 39] Therefore, we expected that Ebi2fl/fl‐LysM‐Cre mice might exhibit reduced infiltration of myeloid cells during the development of SLE. Here, GPR183 is linked to systemic lupus erythematosus.