GPR183 and systemic lupus erythematosus: Next, we investigated how EBI2‐deficient macrophages affect the development of SLE in vivo using TMPD‐induced lupus model, which features the development of lipogranulomas adhering to peritoneal mesothelial cell surface and diffuse pulmonary hemorrhage (DPH).[23, 38] Compared with WT mice, more Ebi2‐cKO mice developed complete DPH 2 weeks after TMPD injection and displayed more severe hemorrhagic spots in lung and more lipogranulomas at the end of 12 weeks (Figure 8A).