Finally, astrocyte cluster 8 (MMP7, SERPINA3, GZMA, and CLIC1) and microglial cluster 2 (DSG2 and TNFRSF25) were elevated in multiple sclerosis patients and suggested the pathogenic role of these biomarkers during multiple sclerosis progression [128]. This evidence concerns the gene TNFRSF25 and multiple sclerosis.