ASPG and acute lymphoblastic leukemia: Through the progress in the research and therapy of T cell acute lymphoblastic leukemia (ALL) has been ameliorated over the past four decades, the improving the outcome of T cell ALL has been demonstrated with more difficulty and has depended on modifications of standard chemotherapies (high-dose cytarabine, high-dose methotrexate, asparaginase, nelarabine) [85].