Interestingly, dish-coated fibronectin promoted cell proliferation, colony formation, migration, invasion, and tube forming activity of NSCLC cells in vitro, mediated the tumor growth, metastasis, angiogenesis in vivo with FAK, WNT/β-catenin, MAPK/ERK signaling pathways activated. Here, FN1 is linked to non-small cell lung carcinoma.