GFAP and neoplasm: GFAP immunostaining on mouse brain showed that astrocytic scar was attenuated with TBOA and KDS2010 treatment (Supplementary Fig. 9), however, bioluminescence image analyses showed that there were no significant differences in tumor size between groups treated with + TMZ + TBOA and + TMZ + KDS2010, compared to the group treated with TMZ alone (Fig. 5i, j).