PRKN and Parkinson disease: Several genes have been identified as risk factors for PD, including Parkin RBR E3 ubiquitin-protein ligase (PRKN), PTEN-induced putative kinase 1 (PINK1), Leucine-rich repeat kinas 2 (LRRK2), Daisuke-Junko-1 (DJ-1), ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), and β-glucocerebrosidase (GBA1) [127].