Function and molecular mechanism of Sirt3 in MSU crystal-induced inflammation were investigated in bone marrow-derived macrophages (BMDMs), C57BL/6 mouse, and Sirt3<sup>-/-</sup> mouse.<h4>Results</h4>Sirt3 expression was decreased in the PBMCs of patients with gout. This evidence concerns the gene SIRT3 and gout.