Consistent with previous proteomic analyses of AD CSF [25, 26, 41–43], there was a significant increase in Tau (MAPT), 14–3-3 proteins, (YWHAZ, YWHAG, and YWHAE), SMOC1, neurofilaments (NEFM and NEFL) and proteins involved in glucose metabolism in both African Americans and Caucasians with AD compared with race matched controls (Fig. 2A and B). This evidence concerns the gene YWHAZ and Alzheimer disease.