MAPT and Alzheimer disease: Consistent with previous proteomic analyses of AD CSF [25, 26, 41–43], there was a significant increase in Tau (MAPT), 14–3-3 proteins, (YWHAZ, YWHAG, and YWHAE), SMOC1, neurofilaments (NEFM and NEFL) and proteins involved in glucose metabolism in both African Americans and Caucasians with AD compared with race matched controls (Fig. 2A and B).