To confirm that LRRTM4 participated in the progression of CRC, we knocked down and overexpressed LRRTM4 in CRC cell lines and found that LRRTM4 knockdown inhibited cell proliferation, metastasis, the cell cycle, and EMT and increased apoptosis, while LRRTM4 overexpression showed the opposite effects (Figs. 4E-I and 5 A-D, S2A-B). The gene discussed is LRRTM4; the disease is colorectal carcinoma.