Since the enhancers and promoters are common for bidirectional transcription, lncRNA could bind to both the transcription factors and DNA and may strengthen their association, lnc-CTHCC promotes HCC by binding hnRNPK and activating YAP1 transcription [34], PD-L1-lnc promotes the progression of lung adenocarcinoma by directly binding to c-Myc and enhancing its transcriptional activity [35]. Here, CD274 is linked to lung adenocarcinoma.