To investigate the role of lnc-LRRTM4 in CRC progression, we silenced lnc-LRRTM4 in HCT116 and SW480 cells due to its relatively high expression and overexpressed it in LoVo cells with relatively low expression (Figs. 1D and 2 A-B). This evidence concerns the gene LRRTM4 and colorectal carcinoma.