Among them, lncRNAs can regulate gene transcription through in cis and in trans action [19], we detected the subcellular distribution of lnc-LRRTM4 in CRC cells and found that it mainly locates in the nucleus (Fig. 4A), then we analyzed the nearby gene of lnc-LRRTM4 (which is named as LOC101927967) using the NCBI database (https://www.ncbi.nlm.nih.gov) and found that LRRTM4 was the nearest gene of lnc-LRRTM4 (Fig. 4B). The gene discussed is LRRTM4; the disease is colorectal carcinoma.