Among 42 SNPs genotyped, the frequencies of rs34660854 A allele and rs75368165 A allele in ATR gene, and rs3756766 A allele in Cdc25C gene in patients were significantly higher than those in controls, which suggested that these alleles could increase the susceptibility to HIV-1 infection (P = 0.049, OR = 1.234, 95% CI = 1.001–1.521; P = 0.020, OR = 1.296, 95% CI = 1.042–1.611; P = 0.011, OR = 1.392, 95% CI = 1.080–1.794, respectively) (Table 2). This evidence concerns the gene ATR and HIV-1 infection.