GLP1R and atherosclerosis: In a meta-analysis [48] including data from 8 trials comprising 60,080 patients, GLP-1 RA reduced MACE by 14% (HR 0.86, 95% CI 0.80 to 0.93), with no significant heterogeneity between subgroups with or without established ASCVD (P for interaction = 0.18).