In a small non-randomized study [122], 89 patients with T2D and CKD (mean eGFR 34.1 ± 11.5 mL/min/1.73 m2), who were poorly controlled or experienced frequent hypoglycemia on oral ADs or NPH insulin, were prescribed glargine U100 at bedtime. The gene discussed is INS; the disease is chronic kidney disease.