], which included 300 patients with advanced HFrEF (hospitalization in the last 14 days; 59% with T2D; median LVEF of 25%) followed for 180 days, treatment with liraglutide did not reduce the primary endpoint of a global rank score of time to death, time to re-hospitalization for HF, and time-averaged proportional change in NT-proBNP. The gene discussed is NPPB; the disease is hydrops fetalis.