Recent investigations in Caenorhabditis elegans indicate that overexpression of Arl8b significantly decreases Aβ aggregation and neurotoxicity [96], suggesting that the accumulation of lysosomal membranes with Arl8b in AD mouse brains may be a protective cellular response that promotes the degeneration of Aβ aggregates. The gene discussed is ARL8B; the disease is Alzheimer disease.