ARL8B and Alzheimer disease: We found that the immunoreactivity of Arl8a and Arl8b, both specifically recognized by the anti-Arl8a/b antibody (Additional file 1: Table S1), is significantly increased in AD patient brains compared to age-matched controls (Fig. 6a, b), indicating that the abundance of these functionally and structurally closely related proteins is abnormally elevated in AD patient brains.