Herein, we performed a comprehensive analysis on six ST6GALNAC family members, which are responsible for the transfer of sialic acid moiety to α-2,6-junction onto GalNAc, in two independent PCa cohorts containing PCa samples with metastasis (n = 99) and without metastasis (n = 476) in total. This evidence concerns the gene ST6GALNAC4 and posterior cortical atrophy.