We also sought to investigate whether combined anti-CD47 therapy and the anti-HER2 ADC, T-DM1 would be more effective than monotherapy using two in-vivo xenograft models: (1) A BRCA1 mutated high grade serous ovarian cancer model (chemotherapy and PARP inhibitors resistant) that exhibits HER2 and MYC amplification, (2) A very aggressive chemotherapy naïve uterine serous carcinoma model that exhibits HER2 and CCNE1 amplification as well as TP53 and PIK3CA mutations. This evidence concerns the gene TP53 and ovarian serous adenocarcinoma.