This revealed that RNF8low gliomas expressed significantly higher levels of HER2-pY1248 and EGFR-pY1173 than RNF8high gliomas, consistent with the role of receptor tyrosine kinase signaling being a core regulatory circuitry in gliomagenesis (Fig. 6E, F) [45]. This evidence concerns the gene ERBB2 and central nervous system cancer.