Verified deregulation of FAS, PMAIP1 and MDM2 genes via q-RT PCR; MDM2 and p53 proteins through western blot analysis indicate more evidence for the possible role of p53 pathway in pathogenesis of PCOS and how future intervention may reduce rate of p53-dependent apoptosis in these individuals. This evidence concerns the gene TP53 and polycystic ovary syndrome.