DEp53TGs in comparison between PCOS and control group mainly enriched in the p53 signaling pathway (21 genes) which was expected as we enriched DEp53TGs, cellular senescence (11 genes), cell cycle (10 genes), FoxO and PI3K-Akt signaling pathways (7 genes), apoptosis (6 genes), focal adhesion (5 genes), AGE-RAGE signaling pathway in diabetic complications and oocyte meiosis (4 genes) and progesterone-mediated oocyte maturation (3 genes) (adjusted p value < 0.001, Fig. 4b). The gene discussed is TP53; the disease is polycystic ovary syndrome.