OSTN and congestive heart failure: More recently, Musclin was shown to function as an exercise-responsive myokine40, to attenuate the pathogenesis and progression of several cardiovascular diseases including heart failure during pathological overload41, hypertension42, cardiac remodeling and congestive heart failure after myocardial infarction43, and chronic doxorubicin-induced cardiotoxicity44 in animal models.