Although miR-150 is associated with HF in humans [21] and the correlative relationship between miR-150 and SPRR1A in the heart has been shown [13], our studies directly establish the functional relationship between miR-150 and SPRR1A during both post-MI remodeling in mice and HCF activation as well as define an underlying mechanism by which miR-150 affects CF activation. Here, HCFC1 is linked to hydrops fetalis.