MiR-150 KO MI hearts also exhibit increased expression of fibrotic Col5a1, Col6a1, Col1a1, Col3a1, and Ctgf (Figs. 5C, D, and 6A–C) compared to expression in WT controls, but miR-150 KO;Sprr1ahypo/hypo MI hearts exhibit decreased expression of these profibrotic genes (Figs. 5C, D, and 6A–C) compared to miR-150 KO controls. The gene discussed is COL5A1; the disease is myocardial infarction.