SPRR1A and hydrops fetalis: Although these previous studies showed the correlative relationship between miR-150 and Sprr1a in HF, our overall knowledge of their functional actions remains elusive in part because of (i) the lack of mechanistic insight by which the miR-150/Sprr1a dyad regulates HF and (ii) the absence of rigorous studies to establish their direct in vivo functional relationship in HF.