Our current study also demonstrates for the first time that SPRR1A knockdown suppresses HCF proliferation and migration (Figs. 7, 8 and Supplementary Figs. 7, 8) and that Sprr1a knockdown attenuates cardiac fibrosis post-MI observed following miR-150 deletion (Figs. 4–6 and Supplementary Figs. 2,, 3). Here, SPRR1A is linked to fibrosis.