CDKN1A and myotonic dystrophy type 1: Notably, recent findings from DM1 patients’ transcriptomic response to strength training showed that CDKN1A is one of the few genes that is correlated to clinical benefits (i.e., the individuals that experienced greater clinical benefits from strength training showed a stronger reduction in CDKN1A expression)56. RNAseq performed in other tissues such as the frontal cortex showed an enrichment in inflammatory genes compared to healthy individuals, suggesting that the pro-inflammatory signature is a common feature in different DM1 tissues57.