Results showed that downregulated genes are controlled by different transcriptions factors related to myogenesis (e.g., MYF5, MYOD1, MYF6, SIX1), while for the genes upregulated in DM1 the transcriptions factors related to the NF-kB pathway (e.g., NFKB1, NFKB2, REL, RELB) were identified (Fig. 1h, i). This evidence concerns the gene REL and myotonic dystrophy type 1.