Top upregulated genes in DM1 cells included cytokines/chemokines related to inflammation (e.g., CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL8, IL1B, IL6, CSF3), and metalloproteinases (e.g., MMP1, MMP3) (Fig. 1b, c and Supplementary Data 1). The gene discussed is IL1B; the disease is myotonic dystrophy type 1.