Compared to healthy control cells, DM1 cells showed lower expression in genes associated to myogenic markers (e.g., MYF5, MYOD1, MYF6, SIX1), extracellular matrix components (e.g., COL1A1, COL1A2, COL3A1, COL5A2, LAMA2, FN1), Notch signaling (e.g., HEYL, RBPJ), and cell cycle (e.g., CENPF, CCNA2, CCNB1, CCNB2, CDK1, MKI67) (Fig. 1b, c and Supplementary Data 1). Here, COL1A1 is linked to myotonic dystrophy type 1.