CXCL8 and myotonic dystrophy type 1: These findings indicate that the top genes overexpressed in DM1 patients (e.g., STC1, SOD2, MMP1, CXCL5, CXCL8) are canonical SASP markers expressed at the protein level by senescent cells, regardless of the cell type or the senescence inducer (Supplementary Fig. 3a).