By comparing the molecular signature of the senescent and non-senescent clusters versus all the combined clusters found in our control sample, we observed a senescent molecular signature present only in the senescent cluster (CXCL1, CXCL3, CXCL5, CXCL8, MMP1, SOD2); and that the non-senescent cluster in DM1 samples expressed a similar molecular profile as our control sample (Fig. 2e). The gene discussed is CXCL5; the disease is myotonic dystrophy type 1.