Previous analysis of the National Cancer Institute (NCI) Oncogenomics Sarcoma Gene Expression dataset demonstrated that SIX1 mRNA is overexpressed in ES tumors relative to normal tissue (average expression across multiple adult tissues)12, but is not nearly as upregulated as it is in other sarcomas where it is known to promote tumor aggressiveness12,20,22,26. Here, SIX1 is linked to sarcoma.