Previous analysis of the National Cancer Institute (NCI) Oncogenomics Sarcoma Gene Expression dataset demonstrated that SIX1 mRNA is overexpressed in ES tumors relative to normal tissue (average expression across multiple adult tissues)12, but is not nearly as upregulated as it is in other sarcomas where it is known to promote tumor aggressiveness12,20,22,26. The gene discussed is SIX1; the disease is Ewing sarcoma.