Our data indicate that while SIX1 KD is associated with a reduction in EMT gene signatures in ES, SIX1 KD ES cells have reductions in both E-cadherin and N-cadherin expression, and SIX1 drives mixed effects on apoptosis- and chemo-resistance, a divergence from the bona fide EMT driven by SIX1 in carcinomas. The gene discussed is CDH2; the disease is carcinoma.