RBM5 and Huntington disease: Considering firstly that no RBM5 expression, splicing or isoform changes were observed in the HD mouse brain in this or previous studies in R6/2 mice46,53 and secondly that RBPs function in concert with one another3, we propose that the changes in the interaction of RBM5 with other proteins could lead to the misregulation of the RNA-binding ability of RBM5 observed in R6/2 mouse brains.