Interestingly, a significant number (40%) of the identified RBM5 interactors also constitute known HTT interactors (Fig. 6d)79,80, with the shared interactors between RBM5 and HTT highly enriched for proteins involved in mRNA metabolic processes, neuron specific processes and Huntington’s disease (Supplementary Fig. 8e). This evidence concerns the gene RBM5 and juvenile Huntington disease.