After filtering out unspecific binders and considering only interactors significantly enriched with both antibodies (Fig. 6b and Supplementary Fig. 8c, d), we identified a total of 617 RBM5 protein interactors in the WT brain and 600 in the HD brain, with high overlap between the two antibodies, providing a total of 619 protein interactors (Fig. 6b and Supplementary Data 6). The gene discussed is RBM5; the disease is Huntington disease.