However, an extended region of 5 kb upstream to pIII is required for IFN-γ-dependent CIITA expression in macrophage/monocytic lines in a STAT1-dependent fashion, and for the constitutive and IFN-γ-mediated MHC-II expression in melanomas and glioblastomas [[29], [30], [31]]. Here, IFNG is linked to glioblastoma.