The Cancer Genome Atlas Research Network demonstrated that HPV-associated cervical carcinomas exhibit several significantly mutated genes (SMGs) such as SHKBP1 (SH3KBP1 binding protein 1), ERRB3, CASP8 (caspase 8), HLA-A (major histocompatibility complex, class I, A), and TGFR2 (transforming growth factor beta receptor 2). Here, CASP8 is linked to cervical carcinoma.