ASCL1 and lung cancer: Recent studies have discovered molecular subtypes of SCNE lung cancer defined by ASCL1 (achaete-scute family bHLH transcription factor 1), NEUROD1 (neurogenic differentiation 1), POU2F3 (POU class 2 homeobox 3), and YAP1 (Yes1 associated transcriptional regulator) transcription factors [60,61].