IFNB1 and neoplasm: First, we screened recombinant IFNβ, recombinant IFNα, the Toll-like receptor (TLR) 3 agonist polyinosinic:polycytidylic acid (poly[I:C]), and the stimulator of IFN genes (STING) agonist, 5,6-dimethylxantenone-4-acetic acid (DMXAA) for their ability to induce local tumor control.