TLR3 and cancer: Although there was a slight decrease in the efficacy of poly(I:C) in tumors derived from TLR3 knockout (KO) cancer cells, this was not significant (p = 0.08; Figures 5A, 5B, S5A, and S5B), suggesting that TLR3 expression on tumor cells is not sufficient for the anti-cancer effect of poly(I:C).