ABCB4 and cancer: Intrinsic factors also predispose to CVD and cancer.26 For instance, specific age-related somatic mutations, labelled clonal haematopoiesis of indeterminate potential (CHIP), increase the risk of haematological malignancy27 and CVD.28 Other genes involved in drug delivery and metabolism modulate the risk of cancer-therapy-induced cardiotoxicity,26 either by increasing it, such as ATP-binding cassette transporters ABCB4 and ABCC, or by decreasing it, for example, ATP-binding transporters (ABCB1) and solute carriers (SLC28A3).26