In a swine model receiving intracoronary infusions of anthracycline, 18F-FTPP+ showed a partial mitochondrial depolarization in myocardial areas distal to the infused vessel.216 Recently, a radiotracer targeting TSPO, a translocator protein expressed in mitochondrial-activated microglia, has been validated in a model of myocardial infarction.217 This pre-clinical study showed that an early myocardial uptake of 18F-radiolabelled TSPO on PET predicted the subsequent LVEF reduction. Here, TSPO is linked to myocardial infarction.