ALB and Hyperglycemia: At the same time, the uCSF of the model + LPS group showed a continuous increase and was higher than that of the model group but in a up-tendency compared with that of the normal group (P = 0.057) (Fig 1C), and the umALB of the model + LPS group increased significantly compared with both the normal group and the model group (Fig 1F), implying that LPS can persistently significantly elevate urinary albumin in hyperglycemia model animals.