The results showed that LPS alone and hyperglycemia can both induce the activation of Caspase-3, and the protein expression of Caspase-3 in hyperglycemia rats after injection of LPS was not higher than that in the normal group receiving LPS or in hyperglycemia animals, suggesting that LPS did not play a role in promoting apoptosis in the hyperglycemia model. Here, CASP3 is linked to Hyperglycemia.