Among the 100 most related genes of SLC35A2 from GEPIA and the 100 co-expressed network genes from LinkedOmics, 15 co-expressed genes (TIMM17B, APEX2, FTSJ1, RPN1, PRICKLE3, PMM2, SURF4, RPN2, LRRC59, SEC61A1, TMED9, SRPRB, PYCR1, SLC39A7, CDK16) were identified (Fig 4D), which exhibited obvious differences in expression between cancer and normal tissues (Fig 4E). This evidence concerns the gene RPN2 and cancer.