With autophagy assessed in response to liver fibrosis by measuring the expression of LC3B, SQSTM1/p62, and BECN1 (Fig. 1e), the conversion of LC3B-I to LC3B-II was an essential step in the formation of autophagosomes, and the abundance of LC3B-II correlated with the number of autophagosomes. Here, SQSTM1 is linked to Hepatic fibrosis.