IGF2BP3, the protein encoded by this gene was primarily found in the nucleolus, and also known as that HBV-pgRNA (pregenomic RNA) could be a potential biomarker to predict clinical outcome and recurrence of HCC (Ding et al. 2021), thus the pgRNA-IGF2BP3 axis had a crucial function in HBV-associated liver cancer. Here, IGF2BP3 is linked to liver cancer.