BRAF and colorectal cancer: Mutations of the BRAF oncogene, primarily BRAFV600E, are detected in up to 10% of patients with colorectal cancer (Fransen et al. 2004; Souglakos et al. 2009; Roth et al. 2010; Yokota et al. 2011; Clancy et al. 2013; Sinicrope et al. 2015).