This builds upon earlier incorporations of genomic information into the modern framework for DLBCL sub-classification, based on cell-of-origin by gene transcription profiling, and gene rearrangements of MYC, BCL2 and/or BCL6. Chapuy et al. analysed 304 DLBCL cases and identified five genetic clusters with distinct signatures termed C1 to C5 [140], while the National Cancer Institute (NCI) group examined 574 cases to identify seven genetic subtypes termed BN2, A53, EZB (MYC + and MYC-), ST2, MCD, and N1 [141, 142]. Here, MYC is linked to diffuse large B-cell lymphoma.