The three main uterine leiomyoma molecular subtypes include (i) tumors with MED12 point mutations, (ii) tumors with biallelic loss of FH, and (iii) tumors with HMGA2 overexpression, commonly associated with chromosomal rearrangements (in HMGA1/HMGA2 or COL4A5/COL4A6), mainly resulting in the overexpression of these genes or reduced expression of CUX1 or CUL1 due to 7q deletions [6–11]. The gene discussed is HMGA2; the disease is Uterine leiomyoma.